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KMID : 0363220090470010095
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Korean Journal of Dermatology
2009 Volume.47 No. 1 p.95 ~ p.97
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Localized Scleroderma-Like Reaction Induced by Doxifluridine
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Lee Kyung-Moon
Cho Ah-Young
Lee Young
Seo Young-Joon
Park Jang-Kyu
Lee Jeung-Hoon
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Abstract
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Exogenous factors, including environmental substances and drugs, are known to induce scleroderma-like reactions.
Various scleroderma-like reactions induced by anti-cancer drugs have recently been reported. This is the first report
that doxifluridine (Didox), an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU), induced a localized
sclerderma-like reaction. A 51-year-old woman was referred to our clinic with multiple pearly, shiny patches on both
her breasts, her pelvis and her back. After surgical excision and radiation therapy due to her right breast cancer, she
took Didox for 7 months. A skin biopsy specimen revealed that the dermal collagen thickening extended even to the
subcutaneous tissue. The routine laboratory tests were within the normal ranges and the tests for antinuclear antibody
(ANA), anti SS-A antibody, anti SS-B antibody and anti U1-RNP antibody were all negative. After discontinuation
of Didox, the lesions gradually improved. Based on these finding, we diagnosed this case as a localized
scleroderma-like reaction induced by doxifluridine and we should pay attention to detect this adverse effect of the
long term use of doxifluridine.
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KEYWORD
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Doxifluridine, Localized scleroderma-Like reaction
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